نيوسالفارسان

نيوسالفارسان
الأسماء
	اسم أيوپاك Neosalvarsan
	أسماء أخرى Sodium 3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate; Neoarsphenamine;914
المُعرِّفات
رقم CAS
3D model (JSmol)	Interactive image;
ChemSpider	9586 ;
ECHA InfoCard	100.006.613
PubChem CID	9980;
UNII	O7K7R0O4BG ;
CompTox Dashboard (EPA)	DTXSID60196599 ;
	InChI InChI=1S/C13H14As2N2O4S.Na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-22(20)21;/h1-6,17-19H,7,16H2,(H,20,21);/q;+1/p-1 Key: BGYSJUFVJUJSOL-UHFFFAOYSA-M ; InChI=1/C13H14As2N2O4S.Na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-22(20)21;/h1-6,17-19H,7,16H2,(H,20,21);/q;+1/p-1 Key: BGYSJUFVJUJSOL-REWHXWOFAO;
	SMILES [Na+].[O-]S(=O)CNc2cc(/[As]=[As]/c1ccc(O)c(N)c1)ccc2O;
الخصائص
الصيغة الجزيئية	C13H13As2N2NaO4S
كتلة مولية	466.15 g/mol
	ما لم يُذكر غير ذلك، البيانات المعطاة للمواد في حالاتهم العيارية (عند 25 °س [77 °ف]، 100 kPa).
	مراجع الجدول

نيوسالفارسان مركب كيميائي له الصيغة C₁₃H₁₃As₂N₂NaO₄S ، وهو مركب عضوي معدني للزرنيخ. وقد أصبح متاحاً في 1912 وسبق العقار الأكثر سمية والأقل ذوبانا في الماء، Salvarsan كعلاج فعال لمرض الزهري. Because both of these arsenicals carried considerable risk of side effects, they were replaced for this indication by penicillin in the 1940s.

Both Salvarsan and Neosalvarsan were developed in the laboratory of Paul Ehrlich in Frankfurt, Germany. Their discoveries were the result of the first organized team effort to optimize the biological activity of a lead compound through systematic chemical modifications.^[1] This scheme is the basis for most modern pharmaceutical research. Both Salvarsan and Neosalvarsan are prodrugs – that is, they are metabolised into the active drug in the body.

Although, like Salvarsan, it was originally believed to contain an arsenic-arsenic double bond, this is now known to be incorrect for Salvarsan.^[2] Presumably, Neosalvarsan also exists as a mixture of differently sized rings with arsenic-arsenic single bonds.

المصادر

[1]

^ Strebhardt K, Ullrich A (May 2008). "Paul Ehrlich's magic bullet concept: 100 years of progress". Nature Reviews. Cancer. 8 (6): 473–480. doi:10.1038/nrc2394. PMID 18469827. S2CID 30063909.
^ Lloyd NC, Morgan HW, Nicholson BK, Ronimus RS (2005). "The Composition of Ehrlich's Salvarsan: Resolution of a Century-Old Debate" (PDF). Angewandte Chemie. International Ed. in English. 44 (6): 941–944. Bibcode:2005ACIE...44..941L. doi:10.1002/anie.200461471. hdl:10289/207. ISSN 1521-3773. PMID 15624113.

هذه بذرة مقالة عن الكيمياء تحتاج للنمو والتحسين، ساهم في إثرائها بالمشاركة في تحريرها.

الكلمات الدالة:

نيوسالفارسان

[1] Strebhardt K, Ullrich A (May 2008). "Paul Ehrlich's magic bullet concept: 100 years of progress". Nature Reviews. Cancer. 8 (6): 473–480. doi:10.1038/nrc2394. PMID 18469827. S2CID 30063909.

[2] Lloyd NC, Morgan HW, Nicholson BK, Ronimus RS (2005). "The Composition of Ehrlich's Salvarsan: Resolution of a Century-Old Debate" (PDF). Angewandte Chemie. International Ed. in English. 44 (6): 941–944. Bibcode:2005ACIE...44..941L. doi:10.1002/anie.200461471. hdl:10289/207. ISSN 1521-3773. PMID 15624113.

[1]

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