كافيدرين Cafedrine

كافيدرين
البيانات السريرية

الأسماء التجارية	Akrinor, Bifort, Praxinor
أسماء أخرى	Caphedrine; Cafedrin; Caphedrin; Kafedrin; Norephedrino-ethyltheophylline; 7-(2-(β-Hydroxy-α-methylphen-ethylamino)ethyl)theophylline
رمز ATC	C01CA21 (WHO)
المعرفات
IUPAC name (RS)-7-[2-[(1-hydroxy-1-phenylpropan-2-yl)amino]ethyl]-1,3-dimethylpurine-2,6-dione
رقم CAS	58166-83-9^Y
PubChem CID	5489638
ChemSpider	4590188^Y
UNII	0UYY5V4U2Q
ChEMBL	CHEMBL2104207^N
CompTox Dashboard (EPA)	DTXSID50866678
Chemical and physical data
التركيب	C₁₈H₂₃N₅O₃
الكتلة المولية	357٫41 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C(CN[C@H]([C@H](O)C1=CC=CC=C1)C)N2C3=C(N(C)C(=O)N(C)C3=O)N=C2
InChI InChI=1S/C18H23N5O3/c1-12(15(24)13-7-5-4-6-8-13)19-9-10-23-11-20-16-14(23)17(25)22(3)18(26)21(16)2/h4-8,11-12,15,19,24H,9-10H2,1-3H3/t12-,15-/m0/s1^Y Key:UJSKUDDDPKGBJY-WFASDCNBSA-N^Y
^NY (what is this?) (verify)

Cafedrine (INN, BAN), sold under the brand name Akrinor among others, is a chemical linkage of norephedrine and theophylline and is a cardiac stimulant and antihypotensive agent used to increase blood pressure in people with hypotension.^[1]^[2]^[3]^[4] It has been marketed in Europe, South Africa, and Indonesia.^[4]^[5]

There has been concern about cafedrine as a potential performance-enhancing drug and doping agent in sports.^[6]

انظر أيضاً

المراجع

^ Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 205. ISBN 978-1-4757-2085-3. Retrieved 29 August 2024.
^ Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. 2013. p. 785. ISBN 978-0-8155-1856-3. Retrieved 29 August 2024.
^ Morton IK, Hall JM (1999). "Calcitonin gene-related peptide receptor antagonist". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 59. ISBN 9789401144391.
^ ^أ ^ب Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 157. ISBN 978-3-88763-075-1. Retrieved 29 August 2024.
^ "Cafedrine". Drugs.com. Retrieved 29 August 2024.
^ Wilson W, Derse E (2001). Doping in Elite Sport: The Politics of Drugs in the Olympic Movement. Human Kinetics. p. 15. ISBN 978-0-7360-0329-2. Retrieved 29 August 2024.

v t e منبهات قلبية عدا الگليكوسيدات القلبية (C01C)
أدرينية Adrenergic والعوامل الدوپامينية dopaminergic	Etilefrine • Isoprenaline • Norepinephrine • دوپامين Dopamine • Norfenefrine • Phenylephrine • Dobutamine • Oxedrine • Metaraminol • Methoxamine • Mephentermine • Dimetofrine • Prenalterol • Dopexamine • Gepefrine • Ibopamine • Midodrine • Octopamine • Fenoldopam • Cafedrine • Arbutamine • Theodrenaline • Epinephrine
مثبط الفوسفودايسترازات Phosphodiesterase inhibitor (PDE3I)	Amrinone • Milrinone • Enoximone • Bucladesine
منبهات قلبية أخرى	Angiotensinamide • Xamoterol • Levosimendan

قالب:Adenosine receptor modulators

v t e Adrenergic receptor modulators
α₁	ناهضات: 6-FNE Amidephrine Anisodine Buspirone Cirazoline Corbadrine Desglymidodrine Dexisometheptene Dipivefrine دوپامين Droxidopa (L-DOPS) Ephedrine إپي‌نفرين Etilefrine Etilevodopa Ethylnorepinephrine Indanidine Isometheptene L-DOPA (levodopa) L-فنايل‌ألانين L-تايروسين Melevodopa Metaraminol Methoxamine ميثيل‌دوپا Midodrine Naphazoline نورإپي‌نفرين Octopamine (drug) Oxymetazoline Phenylephrine Phenylpropanolamine Pseudoephedrine Synephrine Tetryzoline Tiamenidine XP21279 Xylometazoline المستضدات: Abanoquil Adimolol Ajmalicine Alfuzosin Amosulalol Anisodamine Arotinolol Atiprosin Atypical antipsychotics (e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone) Benoxathian Buflomedil Bunazosin Carvedilol Corynanthine Dapiprazole Domesticine Doxazosin Ergolines (e.g., ergotamine, dihydroergotamine, lisuride, terguride) Etoperidone Eugenodilol Fenspiride Hydroxyzine Indoramin Ketanserin L-765,314 Labetalol mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Nicergoline Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine مضادات الاكتئاب (مثل، hydroxynefazodone، نفازودون، ترازودون, triazoledione) Piperoxan Prazosin Quinazosin Quinidine Ritanserin Silodosin Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline مضادات الاكتئاب ثلاثية الحلقة، (e.g., amoxapine, maprotiline, mianserin) Tricyclic antidepressants (e.g., أميترپيتيلين, clomipramine, doxepin, إيمي‌پرامين, trimipramine) Trimazosin Typical antipsychotics (e.g., كلورپرومازين, fluphenazine, loxapine, thioridazine) Urapidil WB-4101 Zolertine
α₂	Agonists: (R)-3-Nitrobiphenyline 4-NEMD 6-FNE Amitraz Apraclonidine Brimonidine Cannabivarin Clonidine Corbadrine Detomidine Dexmedetomidine Dihydroergotamine Dipivefrine دوپامين Droxidopa (L-DOPS) Etilevodopa Ephedrine Ergotamine إپي‌نفرين Etilefrine Ethylnorepinephrine Guanabenz Guanfacine Guanoxabenz L-DOPA (levodopa) L-فنايل‌ألانين L-تايروسين Lofexidine Medetomidine Melevodopa ميثيل‌دوپا Mivazerol Naphazoline نورإپي‌نفرين Oxymetazoline Phenylpropanolamine Piperoxan Pseudoephedrine Rezatomidine Rilmenidine Romifidine Talipexole Tasipimidine Tetrahydrozoline Tiamenidine Tizanidine Tolonidine Urapidil Vatinoxan XP21279 Xylazine Xylometazoline Antagonists: 1-PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics (e.g., asenapine, brexpiprazole, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine) Azapirones (e.g., buspirone, gepirone, ipsapirone, tandospirone) BRL-44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan mCPP Mianserin Mirtazapine NAN-190 Olanzapine Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine SB-269970 Setiptiline Spiroxatrine Sunepitron Tolazoline Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine) Yohimbine
β	Agonists: Abediterol Alifedrine Amibegron Arbutamine Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broxaterol Buphenine Carbuterol Carmoterol Cimaterol Clenbuterol Colterol Corbadrine Denopamine Dipivefrine Dobutamine دوپامين Dopexamine Droxidopa (L-DOPS) إفدرين إپي‌نفرين Etafedrine Etilefrine Etilevodopa Ethylnorepinephrine Fenoterol Formoterol Hexoprenaline Higenamine Indacaterol Isoetarine Isoprenaline Isoxsuprine L-DOPA (levodopa) L-فنايل‌ألانين L-تايروسين Levosalbutamol Mabuterol Melevodopa Methoxyphenamine ميثيل‌دوپا Mirabegron نورإپي‌نفرين Orciprenaline Oxyfedrine PF-610355 Phenylpropanolamine Pirbuterol Prenalterol Ractopamine Procaterol Pseudoephedrine Reproterol Rimiterol Ritodrine Salbutamol سالمترول Solabegron Terbutaline Tretoquinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol المستضدات: Acebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoxime Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol بيسوپرولول Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaxamine Butidrine Butofilolol Capsinolol Carazolol Carpindolol Carteolol Carvedilol Celiprolol Cetamolol Cicloprolol Cinamolol Cloranolol Cyanopindolol Dalbraminol دكسپروپرانولول Diacetolol Dichloroisoprenaline Dihydroalprenolol Dilevalol Diprafenone Draquinolol Ecastolol Epanolol Ericolol Ersentilide Esatenolol Esprolol Eugenodilol Exaprolol Falintolol Flestolol Flusoxolol Hydroxycarteolol Hydroxytertatolol ICI-118,551 Idropranolol Indenolol Indopanolol Iodocyanopindolol Iprocrolol Isoxaprolol Isamoltane Labetalol Landiolol Levobetaxolol لڤوبونولول Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoxolol Nebivolol Nifenalol Nipradilol Oxprenolol Pacrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Procinolol Pronethalol Propafenone پروپرانولول Ridazolol Ronactolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoxolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol

قالب:Cardiovascular-drug-stub